The OHSU Knight Cancer Institute, known as one of the pioneers in personalized cancer medicine, is an international leader in research and cancer treatment. Driven by its mission to end cancer as we know it, the institute is building upon its expertise in targeted treatments to advance the early detection of cancer when the disease is most treatable.

The Center for Experimental Therapeutics at the Knight Cancer Institute is seeking an experienced Assistant Staff Scientist to join the Chemical Biology & Drug Discovery laboratory. Expertise in synthetic organic chemistry is an essential requirement of this position to drive the SAR optimization cycle to achieve project goals. The selected candidate will participate in establishing project goals, defining short and long-term scientific strategies, and contribute to the generation of project-related documents and presentations. They will collaborate with functional and technical experts to facilitate scientific achievement, and will be responsible for compliance with applicable Corporate and Divisional Policies and procedures. They will demonstrate a high degree of responsibility in maintaining scientific standards, and safe laboratory practices for the work unit.

Every Knight Cancer employee is expected to embody our guiding principles:

• We act BOLDLYBreakthroughs require pushing the boundaries of science, exploring new frontiers, and thinking differently


• We SUPPORT each otherRespect leads to trust, which leads to excellence


• We work as a CONNECTED team We must leverage our collective brain power to conquer cancer because no one individual can do it alone

Duties Include:

• Conceive and executesynthetic/ medicinal chemistry research and development that achieves project and area goals. Generate new scientific synthetic and medicinal chemistry proposals and lead those efforts. Investigate, identify, develop, and optimize new methods/ techniques.


• Critically evaluate relevant scientific advances and integrate this knowledge into research programs. Maintain a high level of productivity in the laboratory setting. Demonstrate the ability to resolve key project hurdles and assumptions by effectively utilizing available information and technical expertise.


• Publish research in peer-reviewed journals and present work at scientific conferences. Proactively seek out new information in the literature and incorporate this into individual project(s) as well as the overall program. Effectively write and/or communicate research and regulatory materials.


• Build strong relationships with peers and cross functionally with partners outside of teams to enable higher performance.

• Doctoral degree in medicinal/organic chemistry or a related discipline


• Strong background and training in synthetic methodologies, retro-synthetic analyses, purification, and verification of chemical structure (e.g., NMR, mass spec, FT-IR, etc.)


• Experience in designing and synthesizing structure-activity relationship (SAR) sets


• Must have the ability to interact with an interdisciplinary group including disease area biologists, chemists, data analysts, laboratory biologists, and computer scientists


• Ability to prioritize multiple tasks at one time


• Excellent communication, analytical and organizational skills: both written and verbal, with the ability to develop, implement and clearly communicate chemistry strategies and progress to team


• Ability to work independently and as part of a team while being collaborative in resolving problems


• Must be proficient with computers running Windows and PC applications e.g. MS Excel,Word and PowerPoint)

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