The Institute for Neurodegenerative Diseases (IND) at the University of California, San Francisco (UCSF) is seeking an outstanding and motivated individual to join our cutting-edge drug discovery effort. S/he would immediately contribute to ongoing drug and discovery programs for neurodegenerative diseases, including Creutzfeldt-Jakob disease (CJD), Alzheimer's disease (AD), frontotemporal dementia (FTD) and Parkinson's disease (PD). The IND is building a highly focused and multidisciplinary team to discover the causes of disease, and develop effective pharmacologic treatments, cures and diagnostic markers for these diseases.
The IND is located at the new Sandler Neurosciences Center at UCSF's Mission Bay campus and directed by Nobel Laureate Dr. Stanley Prusiner.
The successful applicant will be an outstanding mass spectrometry researcher, responsible for applying mass spectrometry techniques to quantify biomarkers of neurodegenerative disease and identify pharmacodynamic biomarkers of therapeutic interventions. S/he will collaborate with team members across disciplines to characterize different conformations of disease-relevant proteins and, with laboratory staff, will be responsible for continued operation and maintenance of both ultra-high resolution and imaging mass spectrometers.
The incumbent will have the opportunity to learn and use MS imaging instrumentation for the analysis of the spatial distribution of target proteins and candidate drugs in brain tissues from rodent models of neurodegenerative disease.
Personal Qualifications We expect the incumbent to possess a high sense of responsibility for his or her own career development, as well as for the wellbeing of our organization. The person should be willing to learn new skills and be open to guidance and suggestions from other lab members.
Excellent oral and written communication, organizational and record-keeping skills, and the ability to work as an effective and efficient team member with colleagues and peers within and outside of the IND
Potential to contribute to manuscripts reporting research results
Educational Qualifications:
PhD or ten or more years of experience demonstrating expertise in the relevant specialization to be appointed at the Full rank
BS/MS with 5+ years of related work experience in Analytical Chemistry, Bioanalytical Chemistry, Biochemistry, or a related science to be appointed at the Assistant or Associate rank.
Technical Qualifications Required:
Demonstrated expertise in mass spectrometry of proteins and peptides including quantitative proteomics, peptide mapping, intact protein analysis, post-translational modifications
Demonstrated expertise with MALDI mass spectrometry
Candidate's must meet the qualifications at the time of appointment. Candidate's CV and/or cover letter must state basic qualifications (or if pending) upon submission.
Preferred:
A strong publication record in peer-reviewed journals
Actual hands-on experience, responsibility, and accountability for operation and maintenance of high-resolution mass spectrometers
Expertise with various biological matrices, including brain, liver and/or kidney
Computer software and programming skills
This is a full-time position with excellent benefits. Rank within the Specialist series, and salary will be dependent upon experience.
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.
UC San Francisco seeks candidates whose experience, teaching, research, or community service that has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.
San Francisco, CA
Internal Number: JPF03341
About University of California San Francisco
The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and high-quality patient care. It is the only UC campus in the 10-campus system dedicated exclusively to the health sciences.
